Nutritional - DMG/TMG
Treatment Overview
Dimethylglycine and Trimethylglycine (commonly known as DMG and TMG), are classified
as a food substance rather than a vitamin. It is found in very small amounts
in brown rice and liver. The benefits from taking DMG or TMG range from behavioural
changes, reduction of seizures,and decreased obsessive-compulsive behaviors
to improved language
DMG and TMG have been reported from thousands of families to be
quite beneficial to many autistic individuals. Similar to vitamin B6 and
magnesium, DMG and TMG are safe, relatively inexpensive, and helps about half of autistic
children and adults. It should be noted that some kids tolerate DMG but not TMG.
Also note that whichever one of these is used, it needs to be balanced with folic acid and vitamin B12.
Research on humans and laboratory animals have shown that DMG and TMG enhances the
effectiveness of the immune system. Some autistic children and adults have seizures, and there
are two published reports of decreases in seizure activity as a result of DMG
Two studies have shown no improvements from DMG in autistic individuals; however,
at least one of the studies used only half the recommended dose. In a double-blind
placebo-controlled study by Drs. Shin-siung Jung, Bernard Rimland, and Stephen M. Edelson
involving 84 participants documented a significant
decrease in behavior problems.
References
- Boman W.N. and Richmond, J.A., A double-blind, placebo-controlled, crossover, pilot trial of low dose dimethylglycine in patients with autistic disorder, J. Autism Dev. Disord 29 no 3 (1999) 191-194.
- Kern, J.K., Miller, V.S., et al, Effectiveness of N, N-dimethylglycine in autism and pervasive developmental disorder, J. Child Neurol 16 no 3 (2001) 169-173.
- Hariganesh, K. and Prathiba, J., Effectiveness of dimethylglycine on gastric ulcers in rats, J Pharm. Pharmacol. 52 no 12 (2000) 1519-1522.
- Graber, C.D., Goust, J.M., et al., "Immunomodulating properties of dimethylglycine in humans, J. Infect. Dis. 143 no.1 (1981) 101-105.
- Vojdani, A., Pangborn, J.B., et al., Infections, toxic chemicals and dietary peptides binding to lymphocyte receptors and tissue enzymes are major instigators of autoimmunity in autism, Iny J Immunopath Pharm 16 no.3 (2003) 189-199.
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